Transplanting organs across blood group barriers
In living donation, when organ donor and recipient do not have matching (compatible) blood groups, it is necessary to remove the blood group antibodies (isohemagglutinins) from the recipient to prevent rejection of the transplanted organ. AB0 immunoadsorption enables AB0-incompatible transplantation - of organs such as kidney, liver, lung, heart - and thus contributes to performing more transplantations. The specific removal of blood group antibodies (anti-A/B antibodies) through immunoadsorption is a well-established and highly effective method for many years.
Specific is advantageous
In specific AB0 immunoadsorption, essential plasma components are preserved - an important advantage over nonspecific immunoadsorption and plasma exchange in terms of tolerability. The specific removal of blood group antibodies while retaining important immunoglobulins for infection defense can reduce the risk of severe postoperative infections.
How is the treatment performed?
The AB0 immunoadsorption is well-established in the routine of major transplant centers, with various protocols used as part of individual therapy planning. The Secorim AB0 immunoadsorption can be easily and quickly performed using the Plasauto SIGMA device technology or alternatively with centrifuges - without limitation of the treated plasma volume and with high plasma flow rates of up to 70 ml/min. The duration of the treatment ranges from 2.5 to 6 hours.
How does SECORIM AB0 immunoadsorption work?
In AB0-specific immunoadsorption, the organ recipient's blood (red) is directed through a central venous access into the plasma separator or centrifuge. Inside the separator or centrifuge, the plasma (yellow) is separated from the cell-rich fraction of the blood. This plasma contains the blood group antibodies. The anti-A/anti-B antibodies are then specifically bound to ligands present in the adsorber. After this process, the treated plasma is returned to the patient along with the cell-rich blood. Secorim AB0 adsorbers are disposable columns, with a fresh adsorber used for each treatment.
How is AB0 immunoadsorption reimbursed?
In Germany, AB0 immunoadsorption is implemented in the coding system for hospital reimbursement with the OPS code 8-821.0. The reimbursement rate for AB0 immunoadsorption must be negotiated individually by each hospital.
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The following information is intended for healthcare professionals only.
The information in the section ‚products & therapies‘ is intended to provide explanatory, scientific, and evidence-based answers to medical questions about therapeutic apheresis.
This information does not constitute medical advice. The responsibility for patient care rests with the healthcare professional based on their professional licensure, experience, and knowledge of the patient.