Double Filtration (DFPP)

Double Filtration quickly and effectively removes large blood proteins when they are highly elevated and may be pathogenic. The Rheofilter® ER-4000 selectively removes triglycerides, immunoglobulin M, fibrinogen, LDL cholesterol and other very large blood proteins. The patient only gets his own "purified" blood back. In contrast to plasma exchange, in which the entire blood plasma is discarded and replaced with foreign protein, the DFPP is thus more selective and better tolerated.

Double Filtration with the Rheofilter ER-4000.

Acute inflammation of the pancreas due to increased triglycerides

In healthy people, the concentration of triglycerides, a part of the blood lipids, in the blood sober is below 150 mg / dl. In acute inflammation of the pancreas (acute pancreatitis), however, the triglycerides may be greatly increased in individual cases with more than 1,000 mg/dl. Diabetes and lipid metabolism increase this risk. There is then a hypertriglyceridemia. Therefore, in acute pancreatitis always the tryglycerides in the blood should be determined.

In specialized hospitals, triglycerides can be quickly and effectively reduced with the double filtration (DFPP) blood purification process.

In patients with recurrent inflammation of the pancreas due to increased triglycerides, an outpatient weekly long-term treatment should be considered. In reasonable individual cases, the health insurances will pay for the treatment costs on request in Germany. Please, also ask your doctor for advice.

Triglycerides can also be highly increased during pregnancy. In severe cases, double-filtration (DFPP) can be used in specialized clinics whenever the administration of medication is not possible.

Refsum disease

The so-called Refsum disease, also known as Morbus Refsum, is a hereditary metabolic disorder which results in a large build-up of phytanic acid in the body. This results in phytanic acid depositions which are found frequently in the fatty tissue, the eyes, the heart, the liver and the kidneys and which are associated with a functional limitation of these organs.

Patients with Refsum disease are subject to a strict diet which is hardly compatible with the everyday life and leads to excessive weight loss. Since the phytanic acid mainly takes up by lipoproteins in the blood, there is the possibility to remove these particles from the blood plasma by filtration. 

DIAMED provides Double Filtration (DFPP) for the treatment of Refsum disease, a procedure in the area of therapeutic apheresis. When the disease progresses in spite of the special diet, a special variant of DFPP can be an appropriate therapeutic option. 

Double Filtration in practice

Retinitis pigmentosa and Refsum disease? 

If you have been diagnosed with retinitis pigmentosa, a disease of the retina, you should ask your doctor about the possibility of Refsum disease, especially if you additionally recognize some of the following symptoms: 

  • Nerve injuries (polyneuropathies)
  • Unsteady when walking
  • Malfunction of the olfactory sense
  • Hearing impairment
  • Cardiac arrhythmias
  • Shortened metacarpus / metatarsal bones.

Other diseases which are treated with Double Filtration

Monoclonal gammopathies are changes in the proteins of the blood plasma. It is characterized by a pathological increase of a single immunoglobulin that can lead to serious arterial and venous circulation disturbances. Examples are the IgM plasmocytome and cryoglobulinemia. A variant of DFPP is used for the acute treatment of these diseases in hospitals and university hospitals.

Further information about Double Filtration

In principle, we recommend that you consult the doctor who is treating you. 

For a better understanding of other technical terms, please also refer to our Glossary. 

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