Double filtration: selective, gentle - targeted!

Double-filtration plasmapheresis (DFPP) rapidly and effectively removes high-molecular-weight plasma proteins when they are highly elevated and pathogenic. Following plasma separation, triglycerides, immunoglobulin M, fibrinogen, LDL cholesterol and other high molecular weight proteins are selectively retained in the secondary filter, the Rheofilter® ER-4000. The patient only gets his own "purified" blood back. In contrast to plasma exchange, where all plasma is discarded and foreign protein is substituted, DFPP is more selective and better tolerated.

Doublefiltration Plasmapheresis (DFPP) using the Rheofilter ER-4000

The DFPP significantly improves the circulation of peripheral parts of the body and their oxygen supply. The oxygen partial pressure, measured on the feet, is significantly increased. In addition to the removal of high molecular weight plasma proteins, the improvement of the flow properties of the blood is an additional and desired therapeutic effect.


Microcirculation disorders are often associated with elevated levels of triglycerides, LDL cholesterol or high molecular weight plasma proteins such as immunoglobulin M or fibrinogen. Few double filtrations are usually enough to quickly and sustainably lower triglycerides.

Life-threatening pancreatitis is one of the clinical challenges in acute but also chronic, severe hypertriglyceridemias with values ​​of 3,000 to> 5,000 mg / dl (34-57 mmol / l).

    Double Filtration - Selection of indications
  • Hypertriglyceridaemia (e.g. in pancreatitis)
  • Hyperviscosity syndrome
  • Morbus Waldenström
  • Cryoglobulinaemia
  • Morbus Refsum
  • Sclerodermia
  • Diabetic foot syndrome
  • Loss of hearing / age-related macular degeneration       

Chronic hypertriglyceridemia may also be treated with DFPP on a weekly and an outpatient basis upon request for reimbursement. The same applies to morbus Refsum, a hereditary metabolic disease.

Massive disturbances of the microcirculation in the extremities are caused by high concentrations of paraproteins in hyperviscosity syndrome and by monoclonal immunoglobulin M in Waldenström's disease. In both cases, DFPP is a well-tolerated and highly effective therapy. Rapid and sustained improvement in microcirculation through DFPP is also essential in scleroderma.

In addition, double filtration has a positive influence on wound healing in diabetic foot syndrome. Amputation may be prevented.

Do you have any questions about Double Filtration (DFPP)? Then we would be happy to help you. diamed(at)

In principle, we recommend that you consult the doctor who is treating you.

You will find further information on the treatment of disorders of microcirculation with DFPP in our Information for Patients. For a better understanding of other technical terms, please also refer to our Glossary.


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