Tryptophan immunoadsorption -
Rapid and targeted removal of autoantibodies

For patients suffering from severe forms of autoimmune diseases involving antibodies and and for whom traditional therapies are no longer effective, immunoadsorption (or immunoapheresis) is a proven and effective therapy method in clinical practice. For more than 20 years in this case tryptophan immunoadsorption of DIAMED is an established therapeutic option. Immunoadsorption is used to treat many medical conditions:

Application areas of tryptophan immunoadsorption - a selection

        Neurology
 
  • Multiple sclerosis (MS)
  • Guillain-Barré syndrome (GBS)
  • Myasthenia gravis (MG)
  • CIDP
  • Neuromyelitis optica (NMO)
  • Autoimmune encephalitides
   Cardiology
 
  •  Dilatated cardiomyopathy (DCM)
   Transplantation
 
  •  Antibody-mediated rejection
    Nephrology
 
  • Goodpasture syndrome
  • FSGS
  • Systemic lupus erythematodes (SLE)
  • Wegener's granulomatosis
   Dermatology
 
  •  Pemphigus
   Hematology
 
  • Acquired hemophilia A
  • Thrombotic thrombocytopenic purpura (TTP/ITP)

In immunoadsorption a special filter, the plasma separator, separates the patient's blood into a cell-rich fraction and plasma. Autoantibodies are retained from the plasma by the tryptophan adsorber Immusorba® TR-350. For each treatment, a fresh, new adsorber is used. The patient’s own purified plasma – re-combined with the cell-rich blood - is led back to the patient subsequently.

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Flow chart of tryptophan immunoadsorption with the adsorber TR-350

The active principle of tryptophan immunoadsorption is based on three mechanisms:

  • Immunoadsorption immediately removes autoantibodies from the blood.
  • The removal of autoantibodies from the blood causes a pulse-like redistribution from the extravascular space. Here you will find about 50% of the autoantibodies, which are now entering the bloodstream.
  • Immunoadsorption effects a diverse immune modulation. This is still detectable after one week and may explain the long-lasting clinical benefit of a few months.

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Do you have any questions about Immunadsorption? Then we would be happy to help you: diamed(at)diamed.de

In principle, we recommend that you consult the doctor who is treating you.

You will find further information on diseases treated with Immunoadsorption in our Informations for Patients. For a better understanding of other technical Terms, please refer to our Glossary.

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